- Research Scientist ¦
Priti's research focuses on engineering chromatin loops to precisely regulate gene expression. She aims to develop innovative CRISPR/Cas strategies to modulate chromatin organization for potential therapeutic applications in X-linked disorders.
Education:
Publications:
Belleville A, Thomas J, Tonnies J; Gabel A, Rossi AB; Singh P; Queitsch C, Bradley RK (2024) An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth. Plos Genet, 20(8): e1011363. link
Ding X*, Singh P*, Schimenti K, et al (2023) In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes. Proc Natl Acad Sci USA 120:e2219925120. link
Singh P, Fragoza R, Blengini CS, et al (2021) Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging. Nat Commun 12:5005. link
Ding X, Fragoza R, Singh P, et al (2020) Variants in RABL2A causing male infertility and ciliopathy. Hum Mol Genet 29:3402–3411. link
Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P et al (2020) Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene. Proc Natl Acad Sci USA 117:13680–13688. link
Molaro A, Wood AJ, Janssens D, et al (2020) Biparental contributions of the H2A.B histone variant control embryonic development in mice. PLoS Biol 18:e3001001. link
Palmer N, Talib SZA, Singh P, et al (2020) A novel function for CDK2 activity at meiotic crossover sites. PLoS Biol 18:e3000903. link
Singh P, Patel RK, Palmer N, et al (2019) CDK2 kinase activity is a regulator of male germ cell fate. Development 146:. link
Schimenti J, Singh P (2018) Spermatocytes. In: Reference module in biomedical sciences. Elsevier
Singh P, Aggarwal LM, Parry SA, Raman MJ (2018) Radiation dosimetry and repair kinetics of DNA damage foci in mouse pachytene spermatocyte and round spermatid stages. Mutagenesis 33:231–239. link
Singh P, Schimenti JC (2015) The genetics of human infertility by functional interrogation of SNPs in mice. Proc Natl Acad Sci USA 112:10431–10436. link
Singh P, Schimenti JC, Bolcun-Filas E (2015) A mouse geneticist’s practical guide to CRISPR applications. Genetics 199:1–15. link
Singh P, Raman MJ (2014) Dynamics of radiation induced γH2AX foci in chromatin subcompartments of mouse pachytene spermatocytes and round spermatids. Mol Reprod Dev 81:484–496. link