Publications

Publications

Zalatan J.G., Lee M.E., Almeida R., Gilbert L.A., Whitehead E.H., La Russa M., Tsai J.C., Weissman J.S., Dueber J.E., Qi L.S., and Lim W.A. “Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.” Cell 160, 339-50, 2015.
Featured on the cover of Cell.

Andrews L.D., Zalatan J.G., Herschlag D. “Probing the origins of catalytic discrimination between phosphate and sulfate monoester hydrolysis: comparative analysis of alkaline phosphatase and protein tyrosine phosphatases.” Biochemistry 53, 6811-6819, 2014.

Zalatan, J.G.,* Coyle, S.M.,* Rajan, S., Sidhu, S.S., and Lim, W.A. “Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation.” Science 337, 1218-1222, 2012.

Good, M.C., Zalatan, J.G., and Lim, W.A. “Scaffold proteins: Hubs for controlling the flow of cellular information.” Science 332, 680-686, 2011.

Lassila, J.K.,* Zalatan, J.G.,* and Herschlag D. “Biological phosphoryl-transfer reactions: Understanding mechanism and catalysis.” Annu. Rev. Biochem. 80, 669-702, 2011.

Zalatan, J.G. and Herschlag, D. “The far reaches of enzymology.” Nat. Chem. Biol. 5, 516-520, 2009.

O’Brien, P.J., Lassila, J.K., Fenn, T.D., Zalatan, J.G., and Herschlag, D. “Arginine coordination in enzymatic phosphoryl transfer: Evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase.” Biochemistry. 47, 7663-7672, 2008.

Zalatan, J.G., Fenn, T. D., and Herschlag, D. “Comparative enzymology in the alkaline phosphatase superfamily to determine the catalytic role of an active site metal ion.” J. Mol. Biol. 384, 1174-1189, 2008.

Zalatan, J.G., Catrina, I., Mitchell, R., Grzyska, P.K., O’Brien, P.J., Herschlag, D., and Hengge, A.C. “Kinetic isotope effects for alkaline phosphatase reactions: Implications for the role of active site metal ions in catalysis.” J. Am. Chem. Soc. 129, 9789-9798, 2007.

Catrina, I., O’Brien, P.J., Purcell, J., Nikolic-Hughes, I., Zalatan, J.G., Hengge, A.C., and Herschlag, D. “Probing the origin of the compromised catalysis of E. coli alkaline phosphatase in its promiscuous sulfatase reaction.” J. Am. Chem. Soc. 129, 5760-5765, 2007.

Zalatan, J.G., Fenn, T.D., Brunger, A.T., and Herschlag, D. “Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: Implications for mechanism and evolution.” Biochemistry 45, 9788-9803, 2006.

Zalatan, J.G., and Herschlag, D. “Alkaline phosphatase mono- and diesterase reactions: Comparative transition state analysis.” J. Am. Chem. Soc. 128, 1293-1303, 2006.