- Research Scientist ¦
The aim of Sonya's research is to develop CRISPR-Cas tools to manipulate the inactive X chromosome, either by engineering long-range DNA loops to induce escape from X inactivation or by physically repositioning the chromosome within the nucleus. These tools could then be used to treat diseases that arise from aberrant gene expression from the inactive X chromosome, such as Rett syndrome and systemic lupus erythematous. Sonya's project is a collaboration between the Zalatan, Disteche, and Deng labs at UW.
Education:
Publications:
S.M. Clarkson, D.K. Haja, M.W.W. Adams. (2021) The hyperthermophilic archaeon Pyrococcus furiosus utilizes environmental iron sulfide cluster complexes as an iron source. Extremophiles 25(3):249-256
J. Zha, Y. Zang, M. Mattozzi, J. Plassmeier, M. Gupta, X. Wu, S. Clarkson, M.A.G. Koffas. (2018) Metabolic engineering of Corynebacterium glutamicum for anthocyanin production. Microb. Cell Fact. 17:143.
S.M. Clarkson, R.J. Giannone, D.M. Kridelbaugh, A.M. Guss, J.K. Michener. (2017) Construction and optimization of a heterologous pathway for protocatechuate catabolism in Escherichia coli enables bioconversion of model aromatic compounds. Appl Environ Microbiol 83(18):e01313-17.
B.J. Vaccaro, S.M. Clarkson, J.F. Holden, D.W. Lee, C.H. Wu, F.L. Poole II, J.J.H. Cotelesage, M.J. Hackett, S. Mohebbi, J. Sun, H. Li, M.K. Johnson, G.N. George, M.W.W. Adams. (2017) Biological iron-sulfur storage in a thioferrate-protein nanoparticle. Nat Commun 8:1611.
S.M. Clarkson, S.D. Hamilton-Brehm, R.J. Gianonne, N. Engle, T.J. Tschaplinski, R.L. Hettich, A.M. Guss, J.G. Elkins. A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde tolerance in Thermoanaerobacter pseudethanolicus 39E. Biotechnol. Biofuels 7:165.
S.L. Bridger, S.M. Clarkson, K. Stirrett, M.B. DeBarry, G.L. Lipscomb, G.J. Schut, J. Westpheling, R.A. Scott, M.W.W. Adams. (2011) Deletion strains reveal metabolic roles for key elemental sulfur responsive proteins in Pyrococcus furiosus. J Bacteriol. 193: 6498-6504.
S.M. Clarkson, E.C. Newcomer, E.G. Young, M.W.W. Adams. (2010) The elemental sulfur-responsive protein (SipA) from the hyperthermophilic archaeon Pyrococcus furiosus is regulated by sulfide in an iron-dependent manner. J Bacteriol. 192: 5841-5843.
K.A. Venn, E. Tolstoy, A. Kaufer, E.D. Skillman, S.M. Clarkson, S.J. Smartt, D.J. Lennon, R.P. Kudritzki. (2003) The chemical composition of two supergiants in the dwarf irregular galaxy WLM. Astron J. 126: 1326-1345.