R. Scott McClelland, MD, MPH

Professor of Medicine (AID), Epidemiology, and Global Health

 

Dr. Scott McClelland, MPH, MD, is a Professor of Medicine in the Division of Allergy and Infectious Diseases at the University of Washington. He holds joint appointments in the Departments of Epidemiology and Global Health, and is a member of the University of Nairobi STD/HIV/sexual and reproductive health (SRH) Research Group. Dr. McClelland is a co-Principal Investigator for the University of Washington Vaccine and Treatment Evaluation Unit (VTEU), which includes sites in Seattle, Kenya, South Africa, and Peru. The VTEU conducts non-HIV clinical trials including those directed at pandemic response, respiratory viruses, neglected tropical diseases, malaria, enteric infections, and STIs. Dr. McClelland’s primary research interest focuses on the intersection between infectious diseases and women’s reproductive health. Methodologically, his work spans clinical trials, mHealth interventions, observational epidemiological studies, and implementation research.

Publications

  1. MacLean, F, Zemek, RM, Tsegaye, AT, Graham, JB, Swarts, JL, Vick, SC et al.. Genital herpes shedding episodes associate with altered spatial organization and activation of mucosal immune cells. JCI Insight. 2025; :. doi: 10.1172/jci.insight.197491. PubMed PMID:41252205 .
  2. Sesay, FA, Oware, K, Violette, LR, Donnell, D, Odoyo, JB, Omollo, V et al.. Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis. J Infect Dis. 2025; :. doi: 10.1093/infdis/jiaf519. PubMed PMID:41063661 .
  3. MacLean, F, Zemek, RM, Tsegaye, AT, Graham, JB, Swarts, JL, Vick, SC et al.. Genital herpes shedding episodes associate with alterations in the spatial organization and activation of mucosal immune cells. bioRxiv. 2025; :. doi: 10.1101/2025.06.24.661157. PubMed PMID:40667113 PubMed Central PMC12262732.
  4. Pearson, RA, Krish, KN, Whatney, WE, Jaoko, W, Mandaliya, K, Overbaugh, J et al.. Single-Cell Transcriptomics Reveals Depletion and Dysregulation of Mycobacterium tuberculosis-Specific Th1 and Th17 Cells Early After Acquisition of Human Immunodeficiency Virus. J Infect Dis. 2025;232 (4):835-846. doi: 10.1093/infdis/jiaf354. PubMed PMID:40605619 PubMed Central PMC12526950.
  5. Kwach, B, Kwena, Z, Violette, LR, Rono, B, Odoyo, JB, Oware, K et al.. Understanding barriers and facilitators to doxycycline post-exposure prophylaxis adherence among young women in western kenya: a qualitative study. BMC Infect Dis. 2025;25 (1):855. doi: 10.1186/s12879-025-11209-6. PubMed PMID:40597823 PubMed Central PMC12220084.
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