Seattle Children's

Research Overview

The Millen research lab has long been interested in the genetic and developmental basis of structural birth defects of the brain both in humans and mice. We have a specific interest in malformations of the cerebellum, a brain structure that lies between the brainstem and the cerebrum and plays important roles in sensory perception, motor output, balance and posture in addition to cognition and emotion. The relative anatomic simplicity of the cerebellum makes this important brain structure an ideal system to study neural development. Further, the mechanisms that drive cerebellar development are shared by more complex regions of the brain, including the cerebral cortex.

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