Citation
Castner, D. G. (2017). Biomedical surface analysis: Evolution and future directions. Biointerphases, 12(2).Abstract
This review describes some of the major advances made in biomedical surface analysis over the past 30-40 years. Starting from a single technique analysis of homogeneous surfaces, it has been developed into a complementary, multitechnique approach for obtaining detailed, comprehensive information about a wide range of surfaces and interfaces of interest to the biomedical community. Significant advances have been made in each surface analysis technique, as well as how the techniques are combined to provide detailed information about biological surfaces and interfaces. The driving force for these advances has been that the surface of a biomaterial is the interface between the biological environment and the biomaterial, and so, the state-of-the-art in instrumentation, experimental protocols, and data analysis methods need to be developed so that the detailed surface structure and composition of biomedical devices can be determined and related to their biological performance. Examples of these advances, as well as areas for future developments, are described for immobilized proteins, complex biomedical surfaces, nanoparticles, and 2D/3D imaging of biological materials. (C) 2017 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Keyword(s)
adsorbed protein filmsanalytical electron-microscopycore-shell nanoparticlesion mass-spectrometrymixed DNA/alkylthiol monolayersprincipal component analysisray photoelectron-spectroscopyself-assembled monolayerssum-frequency generationtof-sims analysisNotes
Ev4tgTimes Cited:0
Cited References Count:127
Reference Type
Journal ArticleSecondary Title
BiointerphasesAuthor(s)
Castner, D. G.Year Published
2017Date Published
1496275200Volume Number
12Issue Number
2ISSN/ISBN
1934-8630DOI
Artn 02c30110.1116/1.4982169