Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus

Citation

Alice Pranzetti; Matthew Davis; Chun L. Yeung; Jon A. Preece; Patrick Koelsch; & Paula M. Mendes (2014). Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus. Advanced Materials Interfaces, 1, 1400026.

Abstract

In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.

Keyword(s)

Electrochemistry
self-assembled monolayers
sum frequency generation
switchable surfaces

Reference Type

Journal Article

Secondary Title

Advanced Materials Interfaces

Author(s)

Alice Pranzetti
Matthew Davis
Chun L. Yeung
Jon A. Preece
Patrick Koelsch
Paula M. Mendes