Mechanisms of the Foreign Body Response to RFGD Plasma-Generated PEO-Like Films

Citation

Luisa, M. Szott & Thomas, A. Horbett (2012). Mechanisms of the Foreign Body Response to RFGD Plasma-Generated PEO-Like Films. In Proteins at Interfaces III State of the Art (pp. 321-337). American Chemical Society.

Abstract

Monocyte-derived macrophages play a central role in the foreign body response (FBR) to biomaterials through their interaction with adsorbed proteins on the material?s surface. Fibrinogen (Fg) is a key adhesion protein in the FBR, and much effort has been spent on generating materials that reduce or eliminate its adsorption. However, although ultralow Fg adsorption (< 5 ng/cm2) and almost complete monocyte adhesion resistance was achieved with poly(ethylene oxide) (PEO)-like tetraglyme coatings in vitro, no effect on macrophage adhesion or fibrous capsule formation in mouse in vivo studies was observed. In order to better understand the mechanisms of the FBR to tetraglyme, the role of complement proteins and adsorbed Fg state and their effect on monocyte adhesion in vitro were investigated.

Reference Type

Book Section

Secondary Title

Proteins at Interfaces III State of the Art

Author(s)

Luisa, M. Szott
Thomas, A. Horbett

Year Published

2012

Date Published

1325376000

Volume Number

1120

Issue Number

1120

Pages

321-337

Publisher

American Chemical Society