Citation
Luginbühl, Reto; Overney René, M.; & Ratner Buddy, D. (2000).
Nanobiotribology at the Confined Biomaterial Interface. In
Interfacial Properties on the Submicrometer Scale (pp. 178-196). American Chemical Society.
Abstract
Modern biomaterial research proposes that precision engineered recognition surfaces will trigger biological responses. Ideally, engineered biomaterial surfaces will have mechanical and chemical properties directed to a specific in vivo function. The science of tribology has made a substantial contribution to a better understanding of interfacial problems. We apply in this contribution the term nanobiotribology to embrace all mechanical investigations of biological and biomaterial interfaces at the cellular and molecular level. The potential impact of nanobiotribology to the biomaterial and biomedical science is discussed. Progress in this science field strongly depends on the development of appropriate techniques used to analyze surfaces at the micro- and nanometer level. In the first part, this paper is focused on the possibility of measuring contact mechanical properties on ultrathin biomaterial films with the help of lateral or shear modulation experiments with the scanning force microscope. Shear techniques prove to be in particular successful in determining crosslinking densities and structural phase transitions of ultrathin films. Finally, we will briefly review and critically disscuss recent SFM applications, which were applied to determine molecular interaction forces.
Reference Type
Book Section
Secondary Title
Interfacial Properties on the Submicrometer Scale
Author(s)
Luginbühl, RetoOverney René, M.Ratner Buddy, D.
Year Published
2000
Date Published
977097600
Volume Number
781
Issue Number
781
Pages
178-196
Publisher
American Chemical Society
