Citation
Adden, Nina; Gamble, Lara J.; Castner, David G.; Hoffmann, Andrea; Gross, Gerhard; & Menzel, Henning (2006).
Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces.
Langmuir, 22(19), 8197-8204.
Abstract
Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl)phosphonic acid and (12-carboxydodecyl)phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecules. The reactivity of the surfaces was investigated using trifluoroethylamine hydrochloride and BMP-2. Each step of the surface modification procedure was characterized by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.
Reference Type
Journal Article
Secondary Title
Langmuir
Author(s)
Adden, NinaGamble, Lara J.Castner, David G.Hoffmann, AndreaGross, GerhardMenzel, Henning
Year Published
2006
Date Published
1157068800
Volume Number
22
Issue Number
19
Pages
8197-8204
DOI
10.1021/la060754c
