Citation
Cao, Lan; Ratner, Buddy D.; & Horbett, Thomas A. (2007).
Plasma deposition of tetraglyme inside small diameter tubing: optimization and characterization.
Journal of biomedical materials research. Part A, 81(1), 12-23.
Abstract
In this study, a glow discharge plasma deposition system previously used for treating flat substrates was successfully modified and optimized to produce a PEO-like coating on the inner surface of 1-3 mm ID polyethylene tubing by deposition of tetra ethylene glycol dimethyl ether (tetraglyme). The plasma treatment conditions were varied in order to find operating values that would produce coatings with the ultralow (< 5 ng/cm(2)) fibrinogen adsorption (Gamma(Fg)) previously shown necessary to significantly reduce platelet adhesion. The flow rate of gaseous tetraglyme monomer, pressure, and plasma generating power were found to be the most important parameters affecting the uniformity and chemical structure of the coating. The coating uniformity and quality were assessed by measuring Gamma(Fg) at positions 1 cm apart along the entire tube and the fraction of C1s carbon that was in an ether bond (ether-carbon ratio) by electron spectroscopy of chemical analysis. Under optimized conditions, tetraglyme plasma-coated tubes of up to 20 cm in length had ultralow Gamma(Fg). The region of the tube that had ultralow Gamma(Fg) also had C1s ether-carbon ratios that are greater than 50%.
Keyword(s)
Coated Materials, BiocompatibleEthylene GlycolsHumansPlasmaSurface Properties
Reference Type
Journal Article
Secondary Title
Journal of biomedical materials research. Part A
Author(s)
Cao, LanRatner, Buddy D.Horbett, Thomas A.
Year Published
2007
Volume Number
81
Issue Number
1
Pages
12-23
ISSN/ISBN
1549-3296
DOI
Plasma deposition of tetraglyme inside small diameter tubing10.1002/jbm.a.30906
