Rapidly Biodegrading PLGA-Polyurethane Fibers for Sustained Release of Physicochemically Diverse Drugs

Citation

Blakney, A. K.; Simonovsky, F. I.; Suydam, I. T.; Ratner, B. D.; & Woodrow, K. A. (2016). Rapidly Biodegrading PLGA-Polyurethane Fibers for Sustained Release of Physicochemically Diverse Drugs. ACS Biomater Sci Eng, 2(9), 1595-1607. PMCID: 5630182

Abstract

Sustained release of physicochemically diverse drugs from electrospun fibers remains a challenge and precludes the use of fibers in many medical applications. Here, we synthesize a new class of polyurethanes with poly(lactic-co-glycolic acid) (PLGA) moieties that degrade faster than polyurethanes based on polycaprolactone. The new polymers, with varying hard to soft segment ratios and fluorobenzene pendant group content, were electrospun into nanofibers and loaded with four physicochemically diverse small molecule drugs. Polymers were characterized using GPC, XPS, and (19)F NMR. The size and morphology of electrospun fibers were visualized using SEM, and drug/polymer compatibility and drug crystallinity were evaluated using DSC. We measured in vitro drug release, polymer degradation and cell-culture cytotoxicity of biodegradation products. We show that these newly synthesized PLGA-based polyurethanes degrade up to 65-80% within 4 weeks and are cytocompatible in vitro. The drug-loaded electrospun fibers were amorphous solid dispersions. We found that increasing the hard to soft segment ratio of the polymer enhances the sustained release of positively charged drugs, whereas increasing the fluorobenzene pendant content caused more rapid release of some drugs. In summary, increasing the hard segment or fluorobenzene pendant content of segmented polyurethanes containing PLGA moieties allows for modulation of physicochemically diverse drug release from electrospun fibers while maintaining a biologically relevant biodegradation rate.

Notes

Blakney, Anna K
Simonovsky, Felix I
Suydam, Ian T
Ratner, Buddy D
Woodrow, Kim A
P41 EB002027/EB/NIBIB NIH HHS/
R01 AI112002/AI/NIAID NIH HHS/
ACS Biomater Sci Eng. 2016 Sep 12;2(9):1595-1607. doi: 10.1021/acsbiomaterials.6b00346. Epub 2016 Jul 13.

Reference Type

Journal Article

Secondary Title

ACS Biomater Sci Eng

Author(s)

Blakney, A. K.
Simonovsky, F. I.
Suydam, I. T.
Ratner, B. D.
Woodrow, K. A.

Year Published

2016

Date Published

1757635200

Volume Number

Issue Number

Pages

1595-1607

ISSN/ISBN

2373-9878 (Print)
2373-9878 (Linking)

DOI

10.1021/acsbiomaterials.6b00346

PMCID

5630182