Citation
Chen, Shengfu; Liu, Lingyun; & Jiang, Shaoyi (2006).
Strong Resistance of Oligo(phosphorylcholine) Self-Assembled Monolayers to Protein Adsorption.
Langmuir, 22(6), 2418-2421.
Abstract
In this work, we demonstrate the strong resistance of oligo(phosphorylcholine) (OPC) self-assembled monolayers (SAMs) to protein adsorption and cell adhesion. OPC SAMs were characterized using X-ray photoelectron spectroscopy (XPS), and protein adsorption was measured using a surface plasmon resonance (SPR) sensor. Results are compared with those of phosphorylcholine (PC) SAMs. Despite the existence of negative charge on OPC SAMs and the simple synthesis procedure of OPC thiols, OPC SAMs resist protein adsorption as effectively as or better than PC SAMs formed from highly purified PC thiols. The ease of their preparation and the effectiveness of their function make OPC SAMs an attractive alternative for creating nonfouling surfaces.
Reference Type
Journal Article
Secondary Title
Langmuir
Author(s)
Chen, ShengfuLiu, LingyunJiang, Shaoyi
Year Published
2006
Date Published
1141171200
Volume Number
22
Issue Number
6
Pages
2418-2421
DOI
10.1021/la052851w
