Strong Resistance of Phosphorylcholine Self-Assembled Monolayers to Protein Adsorption:  Insights into Nonfouling Properties of Zwitterionic Materials

Citation

Chen, Shengfu; Zheng, Jie; Li, Lingyan; & Jiang, Shaoyi (2005). Strong Resistance of Phosphorylcholine Self-Assembled Monolayers to Protein Adsorption:  Insights into Nonfouling Properties of Zwitterionic Materials. J Am Chem Soc, 127(41), 14473-14478.

Abstract

In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.

Reference Type

Journal Article

Secondary Title

J Am Chem Soc

Author(s)

Chen, Shengfu
Zheng, Jie
Li, Lingyan
Jiang, Shaoyi

Year Published

2005

Date Published

1128124800

Volume Number

127

Issue Number

41

Pages

14473-14478

DOI

Strong Resistance of Phosphorylcholine Self-Assembled Monolayers to Protein Adsorption10.1021/ja054169u