Surface characterization of biocidal polyurethane modifiers having poly(3,3-substituted)oxetane soft blocks with alkylammonium side chains

Citation

Kurt, P.; Gamble, L. J.; & Wynne, K. J. (2008). Surface characterization of biocidal polyurethane modifiers having poly(3,3-substituted)oxetane soft blocks with alkylammonium side chains. Langmuir, 24(11), 5816-5824.

Abstract

This paper focuses on surface characterization of P[ AB] copolyoxetane soft block polyurethanes having either fluorous (3FOx, -CH2OCH 2CF3) or PEG-like (ME2Ox, -CH2(OCH2CH2) 2OCH3), A side chains and alkylammonium, B side chains. Physical surface characterization data were analyzed in light of the previously observed order of antimicrobial effectiveness for a set of four surface modifiers. Ample physical evidence for surface concentration of fluorous 2 wt % P[ AB]-polyurethane modifiers was obtained from XPS, contact angles, ATR-IR spectroscopy, and TM-AFM. In TM-AFM phase imaging, the most effective biocidal surface modifier, 2 wt % HMDI-BD(30)/P[(3FOx)(C12)-0.89:0.11]-PU, showed a nanoscale phase-separated structure consisting of 200 nm domains with background features about 10 times smaller. Despite similar surface characterization data, the 2 wt % fluorous C6 analog ranked third in contact biocidal effectiveness. Physical evidence for surface concentration of 2 wt % P[(ME2Ox)(C12)-0.86:0.14]-PU was modest, considering that antimicrobial effectiveness was second only to 2 wt % HMDI-BD(30)/P[(3FOx)(C12)-0.89:0.11]-PU. In this set of surface modifiers, nanoscale morphology is largely driven by the fluorous component, whereas antimicrobial effectiveness is more strongly influenced by alkylammonium chain length. The effect of alkylammonium side chain length on surface concentration and antimicrobial behavior is more pronounced for ME2Ox polyurethanes compared to the 3FOx analogs.

Keyword(s)

Anti-Infective Agents/chemical synthesis/*chemistry
Ethers, Cyclic/*chemistry
Hydrocarbons, Fluorinated/*chemistry
Polyurethanes/chemical synthesis/*chemistry
Surface Properties

Notes

Kurt, Pinar
Gamble, Lara J
Wynne, Kenneth J
EB-002027/EB/NIBIB NIH HHS/
Langmuir. 2008 Jun 3;24(11):5816-24. doi: 10.1021/la800203y. Epub 2008 Apr 30.

Reference Type

Journal Article

Secondary Title

Langmuir

Author(s)

Kurt, P.
Gamble, L. J.
Wynne, K. J.

Year Published

2008

Date Published

1748908800

Volume Number

24

Issue Number

11

Pages

5816-5824

DOI

10.1021/la800203y