Alliance for Pandemic Preparedness

February 10, 2020

Clinical characteristics of 2019 novel coronavirus infection in China

Category:

Topic:

  • Clinical characteristics of 1,099 laboratory-confirmed 2019-nCoV patients at 552 hospitals across China (through Jan 29) are described in relation to disease severity and a composite endpoint of ICU admission, mechanical ventilation, and death. Disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count, and chest X-ray/CT manifestations) predicts clinical outcomes
    • Median age of 47 years (only 9 cases below 15 years old)
    • 41.8% female
    • 1.18% had direct contact with wildlife
    • 31.3% had been to Wuhan; 71.8% had contact with someone who had been to Wuhan
    • Symptoms: Fever (87.9%), cough (67.7%), fatigue (38.1%). Diarrhea, uncommon
    • Median incubation period = 3 days (range 0-24)
    • 76.4% had various chest CT abnormalities
    • 79.1% developed pneumonia
      • Median time from symptom onset to pneumonia diagnosis 4 days (range 2-4)
    • 1.4% had died at time of publication 

Guan et al. (Feb 9, 2020). Clinical characteristics of 2019 novel coronavirus infection in China. Pre Print downloaded Feb 9 from https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1