Alliance for Pandemic Preparedness

March 24, 2020

SARS-CoV-2: virus dynamics and host response



  • A cohort study analyzing the viral load and antibody profiles of 23 hospitalized patients with COVID-19 presents important findings: (1) the high viral load during the early phase of illness suggests that patients could be most infectious during this period, (2) the potential for antiviral resistance of SARS-CoV-2, (3) high viral loads in elderly patients could explain the high degree of disease severity. 

Chen and Li (Mar 23, 2020). SARS-CoV-2: virus dynamics and host response. Lancet Infectious Diseases.