Alliance for Pandemic Preparedness

April 14, 2020

No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial

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  • All adults in 4 French hospitals (n=181) with documented SARS-CoV-2 pneumonia were used to emulate a target trial assessing the effectiveness of hydroxychloroquine (HCQ) at 600 mg/day. Findings do not support use of HQC, with no observed reduction in disease severity or death.

Mahevas et al.  (April 14, 2020). No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial. Pre-print downloaded Apr 14 from https://doi.org/10.1101/2020.04.10.20060699