Alliance for Pandemic Preparedness

April 24, 2020

The production and clinical implications of SARS-CoV-2 antibodies



  • Hu et al report on the production of specific IgM and IgG antibodies among 221 confirmed COVID-19 patients, among which were 181 mild and moderate cases and 40 severe cases. The study records the concentration peak of SARS-CoV-2 IgM and IgG antibodies every 3 days post symptom onset and finds that, that although antibody testing on day 16-21 is associated with increased detection rates, the antibody concentration did not affect the course and outcome of the infection. The downward trend of IgG during recovery may indicate its limited duration of protection, a concern seeming to suggest inadequate protective immunity after recovery from infection 

Hu et al. (Apr 23, 2020). The production and clinical implications of SARS-CoV-2 antibodies. Pre-print downloaded Apr 24 from