Alliance for Pandemic Preparedness

April 28, 2020

The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on death and severity of disease in patients with coronavirus disease 2019 (COVID-19): A meta-analysis

Category:

Topic:

  • This meta-analysis includes five studies totaling 308 patients either taking or not taking angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB).  Patients on ACEi/ARB showed a 44% reduction in odds of developing severe disease and a 62% reduction in odds of death when compared to patients not on ACEi/ARB.
  • The authors conclude that it is safe to use ACEi/ARB with COVID-19 patients, and that this data suggests these medications may reduce the risk of developing severe disease and death.

Ghosal et al. (April 28, 2020). The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on death and severity of disease in patients with coronavirus disease 2019 (COVID-19): A meta-analysis. Pre-print downloaded Apr 28 from https://doi.org/10.1101/2020.04.23.20076661