Alliance for Pandemic Preparedness

April 29, 2020

Role of Drugs Affecting the Renin-Angiotensin-Aldosterone System on Susceptibility and Severity of COVID-19: A Large Case-Control Study from Zheijang Province, China

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  • Medical editorials have suggested limited use of ACEI and ARBs in people with arterial hypertension during the COVID-19 pandemic because of increased risk of worse clinical outcomes and that calcium channel blockers (CCBs) should be used as an alternative.  Using a cohort of 610 COVID-19 cases and 48,667 population-based controls from Zheijang, China, Yan et al studied usage of ACEIs, ARBs, CCBs and other medications on risk and severity of COVID 19. The team found no evidence to alter ARBs or ACEIs therapy in the context of the pandemic. COVID-19 patients on corticosteroids are at higher risk of developing a severe form of disease and therefore should be monitored closely.

Yan et al. (April 29, 2020). Role of Drugs Affecting the Renin-Angiotensin-Aldosterone System on Susceptibility and Severity of COVID-19: A Large Case-Control Study from Zheijang Province, China. Pre-print downloaded Apr 29 from https://doi.org/10.1101/2020.04.24.20077875