May 4, 2020

Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• Antibody tests designed to detect envelope protein E and nucleocapsid protein N were conducted on 112 COVID-19 (PCR positive) patients admitted to a hospital in Wuhan, China in February 2020. One hundred and five (93.8%) were positive for either IgM, IgG, or both. Timing of testing with respect to disease onset varied, and was less than 10 days (i.e., possibly prior to antibody production) for 7 participants (two of whom were negative to both IgM and IgG). IgM and IgG titers did not differ between those who were PCR negative versus positive after treatment.  

Zhang et al. (May 2, 2020). Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa229