May 7, 2020

Identification of IgG Antibody Response to SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Does Not Predict Rapid Recovery from COVID-19

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• Quantification of SARS-CoV-2 antibody responses from 20 hospitalized patient with confirmed SARS-CoV-2 infection found that the IgG titers against SARS-CoV-2 spike glycoprotein and its receptor binding domain (RBD) were not associated with their speed of recovery. 
• One patient who recovered completely did not develop RBD antibodies. The authors note that COVID-19 immunity may involve cell-mediated (adaptive T-cell) as well as humoral (antibody) immunity.  

McAndrews et al. (May 6, 2020). Identification of IgG Antibody Response to SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Does Not Predict Rapid Recovery from COVID-19. Pre-print downloaded May 7 from https://doi.org/10.1101/2020.05.01.20087684