May 8, 2020

T Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of COVID-19

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• Among patients hospitalized for COVID-19 (n=103), compared to healthy controls (n=13), there were slight lower CD4+T cells counts but a severe lower CD8+T cell counts in COVID-19 patients. COVID-19 patients with severe disease showed significant decreases in T cell subset counts compared to mild-to-moderate patients. This suggests that T cell subset counts, particularly elevated CD4/CD8 ratios could potentially be used as discriminatory biomarkers for diagnosis and severity prediction. 

Jiang et al. (May 7, 2020). T Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of COVID-19. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa252