May 11, 2020

Liver Injury Is Associated with Severe Coronavirus Disease 2019 (COVID-19) Infection: A Systematic Review and Meta-Analysis of Retrospective Studies

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• A meta-analysis of retrospective studies summarized available findings on the association between liver injury and severity of COVID-19 infection. In total, 20 retrospective studies with 3,428 COVID-19 infected patients (severe cases = 1,455 and mild cases = 1,973), were included.  The incidence of liver injury, as assessed by serum analysis (AST, ALT, total Bilirubin and Albumin levels), seems to be higher in patients with severe COVID-19 versus mild disease. 

Parohan et al. (May 9, 2020). Liver Injury Is Associated with Severe Coronavirus Disease 2019 (COVID-19) Infection: A Systematic Review and Meta-Analysis of Retrospective Studies. Hepatology Research. https://doi.org/10.1111/hepr.13510