May 12, 2020

Rapid Isolation of Potent SARS-CoV-2 Neutralizing Antibodies and Protection in a Small Animal Model

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• Rogers et al. screened over 1,000 antibodies for SARS-CoV-2 using serum from a cohort of recovered patients and an animal model (Syrian hamsters). They report multiple highly potent neutralizing antibodies, and demonstrate that passive transfer of these antibodies provides protection against a high dose viral challenge, suggesting potential for both prevention and treatment of COVID-19. These results may also be used to guide vaccine design.  

Rogers et al. (May 11, 2020). Rapid Isolation of Potent SARS-CoV-2 Neutralizing Antibodies and Protection in a Small Animal Model. Pre-print downloaded May 12 from https://doi.org/10.1101/2020.05.11.088674