May 20, 2020

Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19

Category: Article Summary

Topic: Testing and Treatment

• Suhandynata et al. evaluated the clinical performance of the Diazyme SARS-CoV-2 IgM/IgG serology assay using a cohort of 54 PCR positive patients and an additional 235 negative samples. The assay had a sensitivity of 100% and specificity of 98.7% at 15 or more days after SARS-CoV-2 confirmation. 
• The study also evaluated time to seroconversion in 14 patients who were seronegative on admission. The observed median seroconversion to IgM and IgG was 5 days and 4 days following a positive PCR result, respectively. 

Suhandynata et al. (May 19, 2020). Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19. The Journal of Applied Laboratory Medicine. https://doi.org/10.1093/jalm/jfaa079