Alliance for Pandemic Preparedness

May 21, 2020

Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials

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  • [pre-print, not peer reviewed] Siordia et al. conducted a systematic review and identified 17 COVID-19 treatment trials with viral clearance and clinical outcomes. Favipiravir had a positive impact on symptoms compared to other medications. Lopinavir/ritonavir, hydroxychloroquine, and arbidol (umifenovir) had no statistically significant effects on viral clearance. There was no significant clinical improvement with lopinavir/ritonavir, arbidol, hydroxychloroquine, or remdesivir.  

Siordia et al. (May 20, 2020). Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials. Pre-print downloaded May 21 from https://doi.org/10.1101/2020.05.16.20102095