May 22, 2020

Immunogenic Profile of SARS-CoV-2 Spike in Individuals Recovered from COVID-19

Category: Article Summary

Topic: Vaccines and Immunity

• [pre-print, not peer reviewed] Juno et al. found that following mild to moderate SARS-CoV-2 infection, antibody responses against the viral spike protein are routinely elicited and that they are correlate with the ability of blood plasma to block binding to the ACE2 receptor. This has positive implications for vaccine development because several COVID-19 vaccine candidates that are now entering clinical trials are designed to elicit antibodies that target the viral spike glycoprotein.  

Juno et al. (May 21, 2020). Immunogenic Profile of SARS-CoV-2 Spike in Individuals Recovered from COVID-19. Pre-print downloaded May 21 from https://doi.org/10.1101/2020.05.17.20104869