Alliance for Pandemic Preparedness

May 27, 2020

Correlation between viral RNA shedding and serum antibodies in COVID-19 patients

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  • Jin et al. found that among SARS-CoV-2 infection cases (n=89), serum IgM was significantly higher among those with prolonged viral RNA shedding (>30 days) at weeks 4 and 5 after symptom onset, IgM levels were similar between prolonged and non-prolonged shedders from weeks 6 to 8, and declined almost to the reference level in both groups at week 8. 
  • Serum IgM persisted at a high level during the acute illness and up to 8 weeks after symptom onset. 

Jin et al. (May 18, 2020). Correlation between viral RNA shedding and serum antibodies in COVID-19 patients. Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2020.05.022