Alliance for Pandemic Preparedness

June 1, 2020

The Novel Coronavirus SARS-CoV-2: From a Zoonotic Infection to Coronavirus Disease-19 (COVID19)

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  • A phylogenetic analysis reconstructed from CoV strains demonstrated that SARS-CoV-2, bat RaTG13 and pangolin CoV genomes formed a cluster, suggesting a close relationship between SARS-CoV-2 and bat SARS-like strains, and that pangolins may serve as SARS-CoV-2 intermediate hosts. Some of the observed variations in protein may serve as possible adaptation mutations in humans, but more studies are needed to better understand their function.  

Bezerra et al. (May 29, 2020). The Novel Coronavirus SARS-CoV-2: From a Zoonotic Infection to Coronavirus Disease-19 (COVID19). Journal of Medical Virology. https://doi.org/10.1002/jmv.26072