June 3, 2020

ACE-Inhibitors and Angiotensin-2 Receptor Blockers Are Not Associated with Severe SARS-COVID19 Infection in a Multi-Site UK Acute Hospital Trust

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• It has been hypothesized that ACE-inhibitors and angiotensin-2 blockers, medications commonly prescribed to patients with hypertension or diabetes, could increase the risk of severe COVID-19 infection by increasing the number of ACE2 receptors that SARS-CoV-2 uses for cell entry. However, Bean et al. found no evidence for increased risk of ICU admission or death associated with these medications in a cohort of 1,200 hospitalized COVID-19 patients. 

Bean et al. (June 2, 2020). ACE-Inhibitors and Angiotensin-2 Receptor Blockers Are Not Associated with Severe SARS-COVID19 Infection in a Multi-Site UK Acute Hospital Trust. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1924