Alliance for Pandemic Preparedness

June 4, 2020

Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020

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  • Benameur et al. present a case series of 3 patients with COVID-19 who developed encephalopathy and encephalitis. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM, IL-6, IL-8, and IL-10. No SARS-CoV-2 was identified in any CSF sample. These changes provide evidence of CSF peri-infectious/post-infectious inflammatory changes with neurologic complications. 

Benameur et al. (June 2, 2020). Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020. Emerging Infectious Diseases. https://doi.org/10.3201/eid2609.202122