Alliance for Pandemic Preparedness

June 16, 2020

Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients

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  • Okba et al. validated two ELISA serologic assays for detection of SARS-CoV-2 antibodies. Among 3 PCR-confirmed SARS-CoV-2-cases with serial sample collection, they found that most seroconverted within 2 weeks of disease onset. They found that commercial spike protein subunit 1 IgG or IgA ELISAs had low specificity and sensitivity varied between the 2 assays (the IgA ELISA showed higher sensitivity). These results need to be further validated with a larger cohort. 

Okba et al. (Apr 8, 2020). Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients. Emerging Infectious Diseases. https://doi.org/10.3201/eid2607.200841