Alliance for Pandemic Preparedness

June 18, 2020

Diagnostic Accuracy of Six Commercial SARS-CoV-2 IgGtotal Antibody Assays and Identification of SARS-CoV-2 Neutralizing Antibodies in Convalescent Sera

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  • [pre-print, not peer reviewed] Using a set of 34 serum samples obtained from 26 COVID-19 positive patients with PCR-confirmed SARS-CoV-2 infectionStroemer et al. compared the diagnostic accuracy of six commercially available antibody tests. Sensitivity ranged from 79.4% (Euroimmun) to 96.2% (Abbott). Based on 100 samples from negative individuals, specificity ranged from 97% (Euroimmun) to 100% (Epitope), with 99% sensitivity for Abbot and Roche tests.  
  • A high proportion of serum samples demonstrated neutralizing capacity against SARS-CoV-2. 

Stroemer et al. (June 17, 2020). Diagnostic Accuracy of Six Commercial SARS-CoV-2 IgGtotal Antibody Assays and Identification of SARS-CoV-2 Neutralizing Antibodies in Convalescent Sera. Pre-print downloaded June 18 from https://doi.org/10.1101/2020.06.15.20131672