Alliance for Pandemic Preparedness

June 19, 2020

Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike

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  • [pre-print, not peer reviewed] Among 16 SARS-CoV-2 neutralizing monoclonal antibodies from 5 patients with severe disease, 19 potently neutralized the virus in vitro, 9 with exquisite potency. Several are promising candidates for treatment or prevention of COVID-19. These 19 antibodies were nearly equally divided between two regions at the top of the viral spike — the receptor binding domain and the N-terminal domain — demonstrating the immunogenicity of these regions. 

Ho et al. (June 18, 2020). Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike. Pre-print downloaded June 19 from https://doi.org/10.1101/2020.06.17.153486