June 30, 2020

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• Feldstein et al. identified 186 cases of multisystem inflammatory syndrome in children (MIS-C) between March 15-May 20, 2020 in pediatric health centers in 26 US states. Most children were positive for SARS-CoV-2 (n=131; 70%) and were previously healthy (n=135; 73%). SARS-CoV-2 associated MIS-C led to serious and life-threatening illness: 148 children (80%) received intensive care, 37 (20%) received mechanical ventilation, 90 (48%) received vasoactive support, and 4 (2%) died. 

Feldstein et al. (June 29, 2020). Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2021680