July 1, 2020

Heat Inactivation of Serum Interferes with the Immunoanalysis of Antibodies to SARS‐CoV‐2

Category: Article Summary

Topic: Testing and Treatment

• SARS-CoV-2 antibody levels decreased significantly after heat inactivation of serum at 56 C, which is a proposed method of reducing exposure risk for laboratory personnel. The IgM levels decreased in all 34 serum samples by mean of 54%. IgG levels decreased in 22 of 34 samples (65%) by a mean of 50%. 

Hu et al. (June 28, 2020). Heat Inactivation of Serum Interferes with the Immunoanalysis of Antibodies to SARS‐CoV‐2. Journal of Clinical Laboratory Analysis. https://doi.org/10.1002/jcla.23411