Alliance for Pandemic Preparedness

July 8, 2020

Potential Effective Treatment for COVID-19: Systematic Review and Meta-Analysis of the Severe Infectious Disease with Convalescent Plasma Therapy

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  • Sun et al. conducted a meta-analysis of convalescent plasma treatment for non-SARS-CoV-2 viruses. Across 40 studies of patients infected with SARS-CoV, influenza, or Ebola virus, convalescent plasma was associated with a reduction in mortality, had a low incidence of adverse events, promoted the production of antibodies, reduced viral load, and shortened the disease course. Among 15 controlled studies, mortality was significantly lower among those treated with convalescent plasma than controls (pooled OR=0.31; 95% CI: 0.19-0.52). 

Sun et al. (July 4, 2020). Potential Effective Treatment for COVID-19: Systematic Review and Meta-Analysis of the Severe Infectious Disease with Convalescent Plasma Therapy. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2020.06.107