Alliance for Pandemic Preparedness

July 13, 2020

Intensive Care Admissions of Children with Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) in the UK: A Multicentre Observational Study

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  • Davies et al. conducted a multi-center study of children admitted to PICUs in the UK who met the case definition of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) (n=78). Historical data on admissions for similar conditions found a mean of 1 admission per week, as compared to a mean of 14 cases per week during the study period, with a peak value of 32 admissions in one week.  
  • The median age of patients was 11 years (IQR 8-14), and patients who were male (67%) or members of ethnic minorities (78%) were over-represented relative to their proportions in the general population. Fever, shock, and gastrointestinal symptoms were the most common presenting features. Forty-six percent were invasively ventilated, 36% had evidence of coronary artery abnormalities, 3 (4%) needed extracorporeal membrane oxygenation, and 2 children (3%) died.  

Davies et al. (July 2020). Intensive Care Admissions of Children with Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) in the UK: A Multicentre Observational Study. The Lancet. Child & Adolescent Health. https://doi.org/10.1016/S2352-4642(20)30215-7