July 16, 2020

Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• In a retrospective cohort study of critically ill patients admitted to ICUs in Italy (n=3,988), independent risk factors associated with mortality included older age (HR=1.75), male sex (HR=1.57), history of COPD (HR = 1.68), history of diabetes (HR=1.18), hypercholesterolemia (HR=1.25), and poor respiratory status at ICU admission, as defined by three measures. The hospital mortality rate as of May 30 was 12 per 1000 patient days after a median observation time of 70 days. Eighty-seven percent of patients required invasive mechanical ventilation at the time of ICU admission. Overall mortality was 48% over a median follow-up period of 69 days (range 38-100). 

Grasselli et al. (July 15, 2020). Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2020.3539