July 21, 2020

Neutralizing and Binding Antibody Kinetics of COVID-19 Patients during Hospital and Convalescent Phases

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• [pre-print, not peer-reviewed] Yao et al. analyzed antibody kinetics using 244 serial blood samples from 34 people with COVID-19. All types of antibodies measured were detected approximately two weeks after illness onset. Based on estimated half–life, the authors estimated median times to seronegativity following disease onset to be 4.6 months for IgM (IQR 4.1-5.0), 7.8 months for IgA (IQR 6.7-9.2), and 43 months (IQR 34-48) for IgG. Neutralizing antibodies (Nab) declined faster than IgG but slower than IgM. The relative contribution of IgM to Nab was higher than that of IgG.  

Yao et al. (July 21, 2020). Neutralizing and Binding Antibody Kinetics of COVID-19 Patients during Hospital and Convalescent Phases. Pre-print downloaded July 21 from https://doi.org/10.1101/2020.07.18.20156810