Alliance for Pandemic Preparedness

July 23, 2020

Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a Function of Age and Biological Sex

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  • [Preprint, not peer reviewed] The receptor-binding domain of the CoV spike (RBD-S) protein is important in host cell recognition and infection, and antibodies targeting this domain are often neutralizing. Graham et al. tested anti-RBD-S responses among 32 COVID-19 patients. They found that IgG, IgM, and IgA responses were all induced within 10 days following symptom onset, and IgG response was sustained over a 5-week period. No differences in responses were observed by age or sex, indicating that age-and sex-related disparities in COVID-19 fatality are not explained by anti-RBD-S responses. The authors concluded that the multi-isotype anti-RBD-S response could serve as a potential marker by which to monitor vaccine-induced responses. 

Graham et al. (July 22, 2020). Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a Function of Age and Biological Sex. Pre-print downloaded July 23 from https://doi.org/10.1101/2020.07.15.20154443