Alliance for Pandemic Preparedness

July 29, 2020

Evaluation of the MRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

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  • Corbett et al. report that vaccination of Indian-origin rhesus macaques with mRNA-1273, a vaccine candidate encoding the prefusion-stabilized spike protein of SARS-CoV-2, induced robust antibody and T-cell responses before challenge with SARS-CoV-2 in upper- and lower-airway. Following exposure of the animals to infectious doses of SARS-CoV-2 there was indication of rapid protection from infection and no pathologic changes in the lungs of the animals.  

Corbett et al. (July 28, 2020). Evaluation of the MRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates. New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2024671