July 31, 2020

Single-Shot Ad26 Vaccine Protects against SARS-CoV-2 in Rhesus Macaques

Category: Article Summary

Topic: Vaccines and Immunity

• A single dose of an adenovirus serotype 26 vaccine expressing the SARS-CoV-2 spike protein induced robust neutralizing antibody responses and provided complete or near-complete protection after SARS-CoV-2 challenge in rhesus macaques.  
• A version of the vaccine (Ad26.COV2.S) is currently being evaluated in clinical trials.   

Mercado et al. (July 30, 2020). Single-Shot Ad26 Vaccine Protects against SARS-CoV-2 in Rhesus Macaques. Nature. https://doi.org/10.1038/s41586-020-2607-z