August 6, 2020

Rapid GMP-Compliant Expansion of SARS-CoV-2-Specific T Cells from Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19

Category: Article Summary

Topic: Testing and Treatment

• [Preprint, not peer-reviewed] Cooper et al. isolated CD4 and CD8 memory T cells specific to SARS-CoV-2 spike, nucleocapsid, and membrane antigens from convalescent plasma donors who had recovered from mild SARS-CoV-2 infection. They report that these T cells can be rapidly expanded to therapeutic doses while maintaining the desired central memory phenotype required for protective immune responses against severe COVID-19 infections. 

Cooper et al. (Aug 5, 2020). Rapid GMP-Compliant Expansion of SARS-CoV-2-Specific T Cells from Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19. Pre-print downloaded Aug 6 from https://doi.org/10.1101/2020.08.05.237867