August 10, 2020

Genetic Variability in the Expression of the SARS-CoV-2 Host Cell Entry Factors across Populations

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• Ortiz-Fernández and Sawalha report significant variability in genetic determinants of the expression of ACE2 and TMPRSS2, two enzymes that might regulate the ability of SARS-CoV-2 to infiltrate host cells, among individuals and between populations. 
• African populations showed a genetic predisposition for lower expression of both ACE2 and TMPRSS2 compared to South or East Asians, Europeans, and an “admixed” American population. 

Ortiz-Fernández and Sawalha. (Aug 6, 2020). Genetic Variability in the Expression of the SARS-CoV-2 Host Cell Entry Factors across Populations. Genes & Immunity. https://doi.org/10.1038/s41435-020-0107-7