August 21, 2020

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• [pre-print, not peer-reviewed] Immunologic examinations of 15 people who had recovered from mildly symptomatic, PCR-confirmed COVID-19 found evidence of expanded SARS-CoV-2-specific immune mediators (IgG antibodies and neutralizing plasma, virus-specific memory B and T cells). Responses were persistent, and in some cases increased over three months following symptom onset. They also found that SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral immunity. The authors conclude that these findings provide evidence that recovered individuals will be protected from a second SARS-CoV-2 infection and that Th1 memory should be the target of vaccine elicited memory.

Rodda et al. (Aug 15, 2020). Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Pre-print downloaded Aug 21 from https://doi.org/10.1101/2020.08.11.20171843