August 24, 2020

COVID-19-Associated Hyperinflammation and Escalation of Patient Care: A Retrospective Longitudinal Cohort Study

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Laboratory values indicating hyperinflammation were associated with poor outcomes among patients admitted to hospitals in the UK with COVID-19 (n=269). Patients with hyperinflammation (n=90) had a younger median age (66 vs 71 years) and lower median Charlson Comorbidity Index score (1 vs 2), but a higher proportion of them died during the 28-day follow-up period (40% vs 26%) than patients without hyperinflammation (n=179). Meeting the COVID-19-associated hyperinflammation criteria was significantly associated with the risk of next-day escalation of respiratory support or death (HR=2.24) after adjustment for age, sex, and comorbidity.

Manson et al. (Aug 2020). COVID-19-Associated Hyperinflammation and Escalation of Patient Care: A Retrospective Longitudinal Cohort Study. The Lancet Rheumatology. https://doi.org/10.1016/S2665-9913(20)30275-7