August 26, 2020

An Inflammatory Cytokine Signature Predicts COVID-19 Severity and Survival

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Measurement of inflammatory markers among hospitalized COVID-19 patients (n=1,484) found that high serum IL-6, IL-8, and TNF-α levels at the time of hospitalization were strong and independent predictors of patient survival. IL-6 and TNF-α serum levels remained significant predictors of disease severity and death after adjustment for disease severity, common laboratory inflammation markers, hypoxia and other vital signs, demographics, and a range of comorbidities.

Del Valle et al. (Aug 24, 2020). An Inflammatory Cytokine Signature Predicts COVID-19 Severity and Survival. Nature Medicine. https://doi.org/10.1038/s41591-020-1051-9